When my one girl had to be on anti-biotics she eventually wouldn't take the syringe from the side of her mouth and I accidentally got a drop on her lip and she licked it off. So when I just couldn't get her to cooperate even in a tight burrito (kept managing to get her paws out of the towel) I would just put a drop on her mouth and wait for her to lick and kept repeating until done...it was shockingly less messier that way. I need to practice my burrito skills I'm guessing.