I've never had skin issues with injectible baytril. But I am very careful to not get any baytril in contact with the skin. Typically, I draw the baytril up into the syringe with one needle and put a fresh needle on to inject. If for some reason using two needles isn't an option, I wipe the needle before injecting to remove any baytril from the needle. Baytril is extremely acidic, this is what causes the "burns."