Two of mine couldn't care less. As long as their wheel and dishes are somewhere in the cage, they're fine. Kismet gets very stressed when I move anything in her cage (I suspect she's blind or in the process of going blind), so I try to keep everything as is. When she gets stressed, she goes off her food, has green runny poop and gets very huffy. She'll simply spin in circles, looking distressed.
Play it by ear. I used to move Hemi's cage all the time, rearrange it or build her a completely new enclosure. It never affected her and she always found her way around. In fact, I think she enjoyed it.